NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a total of +1.17 units. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Picks
- Fading the Colts offense may not be the wisest choice, but there's a case for doing so.
Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if the Colts maintain this pace all season long.
Author's summary: Explore 3 plus-money NFL picks for Week 6.